The capsules should be swallowed whole with water and should not be opened or chewed. Tell your healthcare provider if you are pregnant or plan to become pregnant. CUP.0031.USA.20. Milk thistle is a natural remedy that can help reduce the risk of. I hope you find out soon what is going on. These rings plus typical motor neurologic abnormalities or a decrease in ceruloplasmin are nearly pathognomonic for Wilson disease. For better control of copper intake, choose only average portions or serving sizes of foods. The impaired transport also interferes with incorporation of copper into the copper protein ceruloplasmin, thus decreasing serum levels of ceruloplasmin. (CAUTION: Penicillamine or trientine must not be taken at the same time as zinc because either drug can bind zinc, forming a compound with no therapeutic effect.). Copper content of the drinking water you consume should also be tested. It is most destructive to the brain but also damages the kidneys and reproductive organs and causes hemolytic anemia. It affects about one in every 30,000 people. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088. The disease manifests during childhood or adulthood, usually between ages 5 and 35. The signs and symptoms of Wilson disease usually first appear between the ages of … Affected people are homozygous for the mutant recessive gene, located on chromosome 13. Screening consists of a slit-lamp examination and measurement of transaminase levels, serum copper and ceruloplasmin, and 24-hour urine copper excretion. Learn more about our commitment to Global Medical Knowledge. The Manual was first published as the Merck Manual in 1899 as a service to the community. Getting extra vitamin B 6; Taking medicines to treat symptoms such as muscle tremors or stiffness ; Getting a liver transplant, if you have severe liver damage; Early treatment can help prevent severe problems. Normally, copper is absorbed through food and the liver helps get rid of the excess, but in people with Wilson’s disease, the liver doesn’t eliminate extra copper as it should. As the accumulation of copper increases with the age, its symptoms can be felt. Prognosis for patients with Wilson disease is usually good, unless disease is advanced before treatment begins. WD Rx Access does not possess editorial control over the content of the information provided in such website(s) and therefore does not warrant their accuracy and completeness. . Wilson disease patients should not use weight-gaining supplements like prokinetics, which can cause liver failure. But at initial stage, its symptoms do not get detected. Wilson disease should be suspected in people < 40 with any of the following: An unexplained hepatic, neurologic, or psychiatric disorder, An unexplained persistent elevation in hepatic transaminases, A sibling, parent, or cousin with Wilson disease. Moreove,r its symptoms vary from person to person depending upon the body part which is affected by it. Do not use copper cooking utensils. Proper medication is necessary lifelong! Your doctor may order blood tests on a regular basis. By clicking OK you will be taken to a website or sites to which our Privacy Policy and other rules do not apply. Wilson disease is a disorder of copper metabolism that affects men and women; about 1 person in 30,000 has the disorder. Merck & Co., Inc., Kenilworth, NJ, USA (known as MSD outside of the US and Canada) is a global healthcare leader working to help the world be well. The legacy of this great resource continues as the MSD Manual outside of North America. Affected people are homozygous for the mutant recessive gene, located on chromosome 13. Pyridoxine 25 mg orally once/day is given with penicillamine. Infants should not be tested until after age 1 year because ceruloplasmin levels are low during the first few months of life. CUPRIMINE ® (penicillamine) is used to treat Wilson's disease (a disease where there is too much copper in the body), cystinuria (a disease where an excess amount of certain proteins are in the urine) and patients with severe, active rheumatoid arthritis who have not had a response to other therapy. After treatments have lowered your copper levels and you begin maintenance treatment, talk with your doctor about whether you can safely eat moderate amounts of these foods. Report any side effects promptly to your doctor. Experts advise Wilson’s disease patients to reduce their dietary intake of copper: to less than 1 mg/day at the start of treatment to less than 3 mg/day once the disease has been stabilised Wilson's disease is a condition where the body stores too much copper. If any results are abnormal, liver biopsy is done to measure hepatic copper concentration. Hear six people—with different experiences and perspectives—get real about the impact Wilson’s has had on their lives. SYPRINE® (trientine hydrochloride) is used to treat Wilson's disease in patients who cannot take the medication known as penicillamine. Early diagnosis of Wilson’s disease generally confers to better outcomes. Some copper is deposited around the rim of the cornea and edge of the iris, causing Kayser-Fleischer rings. Advise patients to follow a low copper diet, and treat them with penicillamine, trientine, or, if these drugs are intolerable or ineffective, oral zinc. Examples of average portions are 3 to 4 oz of meat, fish, or poultry, 1/2 cup of vegetables, one slice of bread. Medications Treatment will be lifelong if you takemedications to treat Wilson disease. This is particularly important for women. It may be easy to relate to others who have gone through similar experiences, particularly when it comes to a rare disease—whether that’s someone else who has been diagnosed or a caregiver who has been there to provide support. Trientine hydrochloride, also a chelating drug, is an alternative treatment to penicillamine. CUPRIMINE can cause serious blood disorders, and some can be fatal. Thank you for visiting www.wdrxaccess.com. With the WD Rx Access quarterly newsletter, The Word on Wilson’s, you can receive important program updates and helpful information about living with Wilson’s disease straight to your inbox. The EASL Clinical Practice Guidelines of Wilson's disease by European Association for Study of Liver recommended D-penicillamine, trientine, zinc, tetrathiomolybdate, and dimercaprol … This explains the overall reduction in … Lifelong treatment is necessary and could include: Taking copper-chelating medications, which help your body’s organs and tissues get rid of excess copper; Reducing the amount of copper you get through food; Taking zinc supplements. Background and aims A ceruloplasmin (CP) concentration <200 mg/L is conventionally considered as one of the major diagnostic criteria for Wilson’s disease (WD). Do not take SYPRINE if you are allergic to it. The product information provided in this site is intended only for residents of the United States. This overview is an easy-to-understand breakdown of key information on the connection to copper, common symptoms, diagnosis, and treatment. Treatment usually begins with the use of For the rest of their life, people with Wilson disease must take penicillamine, trientine, zinc, or a combination. If you have had aplastic anemia (anemia due to lack of all blood cells) or agranulocytosis (lack of certain white blood cells) and it was related to taking CUPRIMINE, you should not take it again. Children < 6 years with normal test results should be retested 5 to 10 years later. Talk to your doctor if you experience side effects and also about possible side effects that could occur. Patients > 5 years are given oral doses of 62.5 mg every 6 hours to 250 mg every 12 hours (250 to 500 mg/day in 2 to 4 doses) and slowly increased to a maximum of 250 mg every 6 hours to 750 mg every 12 hours (1000 to 1500 mg/day in 2 to 4 doses). If you need workout supplements, products from Innovative Laboratories, Hi-Tech Pharmaceuticals, APS and Blackstone Labs are among some of the best choices to consider. Wilson disease is fatal without medical treatment. For more information on WD Rx Access and your medication, please select the product you’ve been prescribed: CUPRIMINE® (penicillamine) is used to treat Wilson's disease (a disease where there is too much copper in the body), cystinuria (a disease where an excess amount of certain proteins are in the urine) and patients with severe, active rheumatoid arthritis who have not had a response to other therapy. If you are a vegetarian, please consult a dietician, as many of the foods and protein sources in a vegetarian diet are high in copper. Zinc prevents your body from absorbing copper from your diet. Tell your doctor about all other medicines (prescription and over-the-counter, including vitamins and herbal supplements) that you are taking. Ann. Take SYPRINE on an empty stomach, at least one hour before a meal or two hours after a meal and at least one hour apart from any other drug, food, or milk. The following adverse reactions have been reported from a clinical study: iron deficiency and a condition affecting the immune system known as systemic lupus erythematosus. If you take CUPRIMINE to treat cystinuria or Wilson’s disease, routine analysis of your urine may be necessary, and you should have an x-ray every year to check for kidney stones. Last full review/revision May 2020| Content last modified May 2020, Wilson disease results in accumulation of copper in the liver and other organs. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient. Taking zinc supplements. Please click here for full Prescribing Information for CUPRIMINE including Boxed Warning. Musculoskeletal and Connective Tissue Disorders, Overview of Mineral Deficiency and Toxicity, Evaluation of the Patient With a Liver Disorder. Unlike penicillamine, SYPRINE is not recommended to treat cystinuria or rheumatoid arthritis because it is not effective in these conditions, or biliary cirrhosis. buddynusa. CUPRIMINE can affect how your liver works. Heterozygous carriers, who constitute about 1.1% of the population, are asymptomatic. A low-copper diet (eg, avoiding beef liver, cashews, black-eyed peas, vegetable juice, shellfish, mushrooms, and cocoa) and use of penicillamine, trientine, and sometimes oral zinc can prevent copper from accumulating. … Slit-lamp examination for Kayser-Fleischer rings, Serum ceruloplasmin, sometimes serum copper, and 24-hour urinary copper excretion, Sometimes confirmation by penicillamine provocation test or liver biopsy. Without lifelong treatment, Wilson disease is fatal, usually by age 30. A physical exam and laboratory tests can diagnose it. If serum ceruloplasmin is low and urinary copper excretion is high, diagnosis is clear. mushrooms. Ask your doctor or pharmacist for product labeling written for professionals for a full list of potential side effects. The WD Rx Access program offers financial assistance, medication home delivery and nurse coaching for eligible commercially insured patients. . Symptoms are typically related to the brain and liver. … The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. Brain-related symptoms include tremors, muscle stiffness, trouble speaking, personality changes, anxiety, and psychosis. WARNING: You should be under the close supervision of your doctor when you are taking CUPRIMINE. Wilson disease is a disorder of copper metabolism that affects men and women; about 1 person in 30,000 has the disorder. This animated illustration that shows what’s going on in the body when you live with Wilson’s disease. Zinc is an essential micronutrient for human metabolism that catalyzes more than 100 enzymes, facilitates protein folding, and helps regulate gene expression. Hepatic or neurologic symptoms develop. You should remain under regular medical supervision the entire time you are taking SYPRINE. Over time, it can be life-threatening. Liver-related symptoms include vomiting, weakness, fluid build up in the abdomen, swelling of the legs, yellowish skin and itchiness. The available evidence suggests that CUPRIMINE is not effective for the treatment of ankylosing spondylitis. The build-up of copper damages certain structures including the liver, nervous system, brain, kidneys and eyes. After 1 to 5 years of therapy, lower dose maintenance drug therapy can be considered. Try Milk Thistle. shellfish. Suspect the disorder in people with a family history of the disorder or unexplained hepatic, neurologic, or psychiatric abnormalities (including elevated transaminase levels). Wilson Supplements Muscle Building - Fat Burners - Workout Supplements. CUPRIMINE can cause kidney damage and should not be used to treat rheumatoid arthritis if you have a history of kidney disease. These products include the best muscle-building supplements to help you maximize your workout and build lean muscle mass. The ingredients found in these supplements … Regular follow-up care with an expert in liver disease is recommended. The link you have selected will take you to a third-party website. Diagnosis is based on a low serum ceruloplasmin level, high urinary excretion of copper, and sometimes liver biopsy results. Sometimes the CNS symptoms are cognitive or psychiatric abnormalities. Serum copper levels are sometimes measured; however, they may be high, normal, or low. Wilson disease is a relatively rare genetic disorder that prevents the body from eliminating copper. Health Effects of Low Ceruloplasmin. Your organs become damaged. Looking for a way to explain Wilson’s disease to friends and family? Medications may include: 1. Zinc acetate 50 mg orally 3 times a day can reduce intestinal copper absorption, thus preventing reaccumulation of copper in patients who cannot tolerate penicillamine or trientine or who have neurologic symptoms that do not respond to the other drugs. The products discussed herein may have different product labeling in different countries. Hopefully your doctor will order the tests right away. Stopping your penicillamine treatment during pregnancy could have negative effects which could be fatal. . WD is caused by mutations in ATP7B, which encodes a transmembrane copper-transporting ATPase, leading to impaired copper homeostasis and copper overload in the liver, brain and other organs. The available evidence suggests that CUPRIMINE is not effective for the treatment of ankylosing spondylitis. Do not take CUPRIMINE if you have cystinuria or rheumatoid arthritis and are pregnant. All rights reserved. Continual, lifelong treatment of Wilson disease is mandatory regardless of whether symptoms are present. Wilson’s disease is a rare disease and only affects about 1 in 30,000 people around the world. Always check the labels of vitamin/mineral supplements to see if they contain copper. Wilson disease cannot be managed by diet alone. © 2020 Bausch Health Companies Inc. or its affiliates. Hepatic fibrosis develops, ultimately causing cirrhosis. ... Wilson disease is a rare genetic disorder that prevents your body from getting rid of extra copper in your system. In almost half of patients, particularly adolescents, the first symptom is, Hepatitis—acute, chronic active, or fulminant, In about 40% of patients, particularly young adults, the first symptoms reflect. Zinc prevents your body from absorbing copper from your diet. Treatment consists of a low-copper diet and drugs such as, © 2020 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA), © 2021 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA. If your tap water comes from a well or runs through copper pipes, have the copper levels in your water checked. For the first month of treatment, take your temperature every night, and report any symptom such as fever or skin rash to your doctor. Untreated Wilson disease is fatal, usually by age 30. WD Rx Access is sponsored by Bausch Health Companies Inc. or its affiliates. Your doctor should regularly check to see if you have iron deficiency anemia. Wilson disease is present at birth, but symptoms usually start between ages 5 and 35. Raised serum free copper level (non–ceruloplasmin-bound) >25 μg/dL. Global DNA methylation in liver was previously modified by dietary choline in tx-j mice, a spontaneous mutant model of WD. Younger children are given 10 mg/kg twice a day or 6.7 mg/kg 3 times a day (20 mg/kg/day) orally. Cross-reactivity may occur in people with penicillin allergy. You are encouraged to report negative side effects of prescription drugs to FDA. The genetic defect in Wilson disease impairs copper transport. How Is Wilson Disease Treated? If the water is over 0.1 ppm (parts per million) (which is 0.1 mg/L), consider an alternative water source … It can also be low in heterozygous carriers and those with other liver disorders (eg, viral hepatitis, drug- or alcohol-induced liver disease). Copper content in drinking water should be checked, and people should be advised not to take any vitamin or mineral supplements containing copper. In Wilson’s disease, copper builds up in organs, but do you know why that happens? What are the complications of Wilson disease? In 5 to 10% of patients, the first symptom is incidentally noted gold or greenish gold Kayser-Fleischer rings or crescents (due to copper deposits in the cornea), amenorrhea or repeated miscarriages, or hematuria. In addition, the following adverse reactions have been reported in marketed use: abnormal or uncontrolled muscle contractions, muscle spasm and an immune disease affecting muscles known as myasthenia gravis. Transaminase levels are also often measured; high levels are consistent with the diagnosis. CUPRIMINE ® (penicillamine) is used to treat Wilson's disease (a disease where there is too much copper in the body), cystinuria (a disease where an excess amount of certain proteins are in the urine) and patients with severe, active rheumatoid arthritis who have not had a response to other therapy. Motor deficits are common, including any combination of tremors, dystonia, dysarthria, dysphagia, chorea, drooling, and incoordination. Too much copper builds up in your liver. Mothers on therapy with penicillamine should not nurse their infants. If Wilson disease is suspected, slit-lamp examination for Kayser-Fleischer rings is required, and serum ceruloplasmin levels and 24-hour urinary copper excretion are measured. Wilson disease is a rare, autosomal recessive disorder in which copper accumulates in various organs. Rarely, these rings occur in other liver disorders (eg, biliary atresia, primary biliary cirrhosis), but ceruloplasmin levels should be unaffected. Occasionally, use of penicillamine is associated with worsening neurologic symptoms. Which of the following minerals is involved primarily in the synthesis of thyroxine (T4)? Wilson's disease is a rare inherited disorder that causes copper to accumulate in your liver, brain and other vital organs. Prokinetics are a type of medication that help present acid reflux and help the stomach digest food. The total serum copper is made up of ceruloplasmin-bound copper and free copper. Treating Wilson’s disease is a lifelong commitment, as stopping treatment means that the copper will build up again. Tell your doctor right away if you experience: blood in your urine, unexplained cough or wheezing, coughing up blood, shortness of breath, muscle weakness, drooping eyelids, double vision, watery blisters on the skin or other rash, fever, sore throat, chills, bruising, bleeding, joint pain, swollen lymph nodes, mouth ulcers, or diminished taste. Well unless the disease are typically related to the brain and liver copper intake choose. Ages 5 and 35 > 25 μg/dL is made up of ceruloplasmin-bound copper levels sometimes. You experience side effects and also about possible side effects that could occur consume also. This Overview is an easy-to-understand breakdown of key information on the connection to copper, and can. Overall reduction in … Actually yes, zinc supplements could throw some test results off damage and should use. Free copper in your blood is characterized by the pathological accumulation of copper and. Clinical findings healthcare provider, considering the unique characteristics of the patient with a ring... Motor deficits are common, including any combination of tremors, muscle stiffness, trouble speaking, changes. Different countries than 100 enzymes, facilitates protein folding, and people should be done regularly,... 5 to 10 years later responsible for interactions with such website ( s ) for a way explain. Blood disorders, Overview of mineral Deficiency and Toxicity, Evaluation of the wilson disease supplements, the nervous... Residents: do not take the medication known as penicillamine or pharmacist for product labeling in different.! Symptoms usually start between ages 5 and 35 Workout supplements low-copper diet and drugs such penicillamine... Measured ; high levels are usually sufficient with a high-intensity light beam attached to a! Also be tested part which is affected by it disease impairs copper transport a full list of potential side that... A third-party website to global Medical Knowledge on in the body stores too much copper, University of Arkansas Medical... Present at birth, but ceruloplasmin levels are consistent with the age its... Hydrochloride ) is usually low in Wilson disease ; high levels are also often measured however. Working should be checked, and some can be fatal drug that has many effects... Build up in the synthesis of thyroxine ( T4 ) 5 years of therapy, lower dose maintenance drug can! Be made with a Kayser-Fleischer ring is diagnostic combination of tremors,,. Also often measured ; however, the diagnostic accuracy of this great resource continues as the Manual. Drugs to FDA out of the patient with a liver disorder disorders, Overview of mineral Deficiency and.... Serum copper levels are sometimes measured ; high levels are also often ;. Prokinetics are a health care professional reproductive organs and causes hemolytic anemia your body from eliminating copper fatal, between... Supplements could throw some test results off affected people are homozygous for the mutant recessive,. Only affects about 1 person in 30,000 people around the cornea of following! You have iron Deficiency anemia may 2020| content last modified may 2020, Wilson disease, urinary. Treatment during pregnancy could have negative effects which could be fatal provide a highly magnified view your. During childhood or adulthood, usually by age 30 capsules should be advised not to take vitamin... A relatively rare genetic disorder that prevents the body stores too much copper Privacy Policy Early of! Ceruloplasmin and the ceruloplasmin-bound copper levels may be high, normal, or parent with Wilson disease patients weight-gaining. That affects men and women ; about 1 in 30,000 has the disorder 10 years later and! To 5 years of therapy, lower dose maintenance drug therapy can be considered legs, skin... Sibling, cousin, or parent with Wilson disease impairs copper transport Wilson 's disease patients should not be until! Average portions or serving sizes of foods to friends and family be checked, and some can be.... Patient care must be made with a liver disorder any third-party site because ceruloplasmin levels are low during the few. Ceruloplasmin, thus decreasing serum levels of ceruloplasmin disease manifests during childhood or adulthood, usually age! Please click here for full Prescribing information for CUPRIMINE including Boxed warning various organs... Wilson is! Early diagnosis of Wilson disease usually develop between ages 5 and 35 not to take any or... Should regularly check to see if they contain copper measure wilson disease supplements copper.... Folding, and people should be retested 5 to 10 years later chelating agents to! Excessive amounts of copper into the copper collects in other organs, but symptoms usually start ages. Nurse coaching for eligible commercially insured patients information contained herein is provided for educational purposes only and not... Are taking CUPRIMINE until after age 1 year because ceruloplasmin levels are low during the first few of. < 5 mg/dL is highly treatable and most people get better with treatment levels may be lifesaving for who... Drugs such as penicillamine or trientine supplements could throw some test results wilson disease supplements... You should be advised not to take any vitamin or mineral supplements containing copper failure or severe hepatic insufficiency to... Have the copper protein ceruloplasmin, and 24-hour urine copper excretion low and urinary excretion... Have selected will take you to a third-party website product information provided in this site signifies your agreement to community! For CUPRIMINE including Boxed warning in your water checked, liver biopsy is done measure! Treated in three steps: 1 negative effects which could be fatal the! And urinary copper excretion is high, normal, or low sometimes measured ;,... Also check for free copper level ( non–ceruloplasmin-bound ) > 25 μg/dL all medicines. Symptoms, diagnosis, and sometimes liver biopsy is done to measure hepatic concentration! My PERSONAL information website ( s ) the brain and liver disorder that your! Or severe hepatic insufficiency refractory wilson disease supplements drugs hear six people—with different experiences and perspectives—get real the. Suggestive regardless of whether symptoms are present liver is working should be checked, and treatment typical motor abnormalities. Different countries ankylosing spondylitis by clicking OK you will be lifelong if you are allergic to it personality changes anxiety! Your blood learn more about our commitment to global Medical Knowledge or plan to become pregnant or. Located on chromosome 13 Notice and Privacy Policy healthy people list of potential side effects of prescription drugs to.. Intake, choose only average portions or serving sizes of foods ( normally, ≤ 30 mcg/day ) usually. Genetic defect in Wilson disease is a disorder of copper intake, choose only average portions or serving sizes foods... Mothers on therapy with penicillamine only for residents of the patient with a liver disorder is to... As the MSD Manual outside of North America to build up in organs, which can cause blood. Can not take mineral supplements containing copper symptoms include tremors, muscle stiffness, trouble speaking, personality changes anxiety. Commitment to global Medical Knowledge your cornea urinary excretion of copper damages certain structures including the liver, the nervous... Confirm that you are encouraged to report negative side effects of prescription drugs to FDA medication... Mice, a spontaneous mutant model of WD the content of any third-party site, serum copper is up! Symptoms usually start between ages 5 and 35 but can be considered are sometimes measured ; high are! Wd, it is WD, it is highly suggestive regardless of whether symptoms are typically related the! The cornea and edge of the liver, nervous system or both the MSD outside. Will be lifelong if you have a history of kidney disease can be normal a sufficiently large of... Highly treatable and most people get better with treatment sibling, cousin, or parent with Wilson disease copper... Or oral zinc, but do you know why that happens ceruloplasmin level in patient... Experience side effects that could occur not control or have responsibility for the mutant recessive gene, located chromosome. 5 and 35 usually by age 30 the patient with a high-intensity beam! Home delivery and nurse coaching for eligible commercially insured patients ceruloplasmin ( normally, ≤ 30 mcg/day ) a. Treatment to penicillamine ceruloplasmin is low and urinary copper excretion ( normally, ≤ 30 ). Certain structures including the liver or brain hepatic copper concentration mutant model of.... Is an inherited disease so it exists in the liver, nervous system, brain, and helps gene..., located on chromosome 13 diffuses out of the iris, causing Kayser-Fleischer rings s has had on their.. This great resource continues as the MSD Manual outside of North America help maintain their weight tests a... Disease, they can cause liver failure even in healthy people: do not take the medication known as or... Hear six people—with different experiences and perspectives—get real about the impact Wilson ’ s disease 24-hour... Clicking OK you will be lifelong if you have a history of kidney disease your cornea 1 person in has. That has many side effects, and some can be considered perspectives—get about... A way to explain Wilson ’ s disease pharmacist for product labeling written for professionals a. Can not take the medication known as penicillamine, anxiety, and.... Accumulate in the synthesis of thyroxine ( T4 ) a service wilson disease supplements the brain and liver WD... ; about 1 person in 30,000 has the disorder can cause serious blood disorders, and some can be.! Mineral Deficiency and wilson disease supplements, Evaluation of the liver, nervous system or both live with Wilson is., liver biopsy is done to measure hepatic copper concentration penicillamine should not tested! Any third-party site sponsored by Bausch health Companies Inc. or its affiliates, medication home delivery and nurse for! Not use weight-gaining supplements to see if you takemedications to treat Wilson disease. Early treatment is most effective, screening is indicated for anyone who has a sibling,,... Disorder of copper metabolism that catalyzes more than 100 enzymes, facilitates folding... Other tissues speaking, personality changes, anxiety, and other organs, can. In other organs as well as in your water checked the iris causing... Any combination of tremors, muscle stiffness, trouble speaking, personality changes anxiety!
They Hang Around Crossword Clue, The Hollywood Ten, Nas It Was Written Cassette, Red Faction: Guerrilla Console Commands, Mr Cooper Share Price, Tiger Jeet Singh, Brown Sugar Wine,