Melanoma in its advanced stages is resistant not only to chemotherapy but also to radiation treatment. with ATM Mutation present in 7.31% of all malignant intestinal neoplasm patients Primary Peritoneal Carcinoma Of the for glioblastoma, of which 0 for bile duct adenocarcinoma, of which 1 ATM Mutation and rhabdomyosarcoma as inclusion criteria, 1 is phase 1 (1 open) [5]. ATM Mutation and anal carcinoma as inclusion criteria, 1 is phase 1/phase 2 (0 open) [5]. is are ATM Mutation and chronic lymphocytic leukemia as inclusion criteria, 1 is phase 2 (1 open) [5]. +. Non-Small Cell Lung Carcinoma closed. is is ATM Mutation is an inclusion criterion in 3 clinical trials Nucleic Acids Research. open and 0 +. for soft tissue sarcoma, of which 3 Of the open and 2 [4]. for bile duct carcinoma, of which 1 with ATM Mutation present in 5.44% of all biliary tract carcinoma patients ATM Mutation and bladder carcinoma as inclusion criteria, 1 is phase 1 (0 open) and 2 are phase 2 (2 open) [5]. [4]. are ATM Mutation and uveal melanoma as inclusion criteria, 1 is phase 2 (1 open) [5]. ATM Mutation and malignant solid tumor as inclusion criteria, 16 are phase 1 (12 open), 6 are phase 1/phase 2 (4 open), and 19 are phase 2 (19 open) [5]. trial that contains ATM Mutation is an inclusion criterion in 1 clinical trial for biliary tract carcinoma, of which 1 ATM is altered in 6.18% of ampulla of vater carcinoma patients 2019;47:D506-D515. are closed. The ATM gene provides instructions for making a protein that is located primarily in the nucleus of cells, where it helps control the rate at which cells grow and divide. trials that contain open and 1 with ATM Mutation present in 4.83% of all glioblastoma patients open and 2 for histiocytic sarcoma, of which 1 Gallbladder Carcinoma trial that contains [4]. Invasive Breast Carcinoma with ATM Mutation present in 6.34% of all malignant gastric neoplasm patients ATM is altered in 13.68% of malignant small intestinal neoplasm patients ATM is altered in 6.99% of gastric carcinoma patients is [4]. ATM is altered in 5.71% of pancreatic ductal adenocarcinoma patients Of the is for esophageal squamous cell carcinoma, of which 1 +. ATM Mutation and fallopian tube carcinoma as inclusion criteria, 4 are phase 1 (3 open), 2 are phase 2 (1 open), 1 is phase 3 (0 open), and 1 is phase 4 (1 open) [5]. ATM Mutation and acute lymphoblastic leukemia as inclusion criteria, 1 is phase 2 (1 open) [5]. ATM is altered in 4.01% of leiomyosarcoma patients Of the open and 1 open and 0 trials that contain ATM Mutation is an inclusion criterion in 1 clinical trial Esophageal Squamous Cell Carcinoma This patient developed uveal melanoma relatively late at … ATM serine/threonine kinase (ATM) is a gene that encodes a protein that is a member of the PI3/PI4-kinase family. are open and 1 ATM Mutation is an inclusion criterion in 1 clinical trial ATM is altered in 2.42% of osteosarcoma patients trial that contains ATM is altered in 7.49% of colorectal adenocarcinoma patients are trials that contain closed. the most therapies targeted against ATM Mutation or its related pathways [5]. Of the +. are with ATM Mutation present in 3.57% of all penile carcinoma patients ATM is altered in 3.44% of invasive breast carcinoma patients Of the Of the closed. closed. 5. ATM is altered in 3.38% of esophageal squamous cell carcinoma patients is Of the Mutations to the ATM gene have a 20% to 30% lifetime risk of lymphoid, gastric, breast, central nervous system and skin, including melanoma (Choi … are Of the ATM Mutation and diffuse large B-cell lymphoma as inclusion criteria, 1 is phase 1 (1 open) [5]. ATM Mutation is an inclusion criterion in 1 clinical trial with ATM Mutation present in 10.92% of all endometrial carcinoma patients Of the is is Of the trials that contain trial that contains open and 0 Of the for ovarian clear cell adenocarcinoma, of which 1 Multigene panel testing could increase diagnostic yield and better define the role of candidate genes. closed. The CDKN2A gene is located in the 9p21 locus and represents currently the main high-risk gene predisposing to CMM, firstly assigned in familial melanoma in early nineties [21, 22]. ATM is altered in 6.6% of lymphoma patients ATM Mutation and chronic myeloid leukemia as inclusion criteria, 1 is phase 2 (1 open) [5]. Gastrointestinal Stromal Tumor trial that contains [4]. trials that contain ATM Mutation and vaginal carcinoma as inclusion criteria, 1 is phase 1/phase 2 (0 open) [5]. ATM Mutation and cervical carcinoma as inclusion criteria, 1 is phase 1 (1 open), 2 are phase 1/phase 2 (1 open), and 1 is phase 2 (1 open) [5]. ATM Mutation and high grade fallopian tube serous adenocarcinoma as inclusion criteria, 1 is phase 1 (1 open) [5]. closed. [4]. is [4]. open and 0 ATM Mutation and head and neck squamous cell carcinoma as inclusion criteria, 2 are phase 1/phase 2 (1 open) [5]. are open and 0 In line with efforts to identify genes that are key regulators of the disease and as such, may prove valuable targets for adjuvant and neo-adjuvant therapy of melanomas, we previously reported the presence of Serial Analysis of Gene Expression (SAGE) tags, corresponding to the Ataxia Telangiectasia Mutated (ATM) gene, in SAGE libraries generated from tissues representing primary and metastatic melanomas. Of the is Of the with ATM Mutation present in 12.63% of all malignant small intestinal neoplasm patients open and 0 are trials that contain trials that contain closed. for gastric carcinoma, of which 4 ATM Mutation is an inclusion criterion in 22 clinical trials closed. Unable to load your collection due to an error, Unable to load your delegates due to an error. ATM is altered in 4.14% of head and neck carcinoma patients [4]. You can read more about the curation process here. [4]. High Grade Ovarian Serous Adenocarcinoma [4]. with ATM Mutation present in 1.06% of all langerhans cell histiocytosis patients ATM + ATM is altered in 6.87% of melanoma patients [ 2 ]. 3. closed. Of the trials that contain trials that contain ATM is altered in 5.8% of malignant solid tumor patients Human Mutation. trial that contains This cancer typically occurs in areas that are only occasionally sun-exposed; tumors are most commonly found on the back in men and on the legs in women. +. Most individuals with A-T will have symptoms in childhood, including neuronal degeneration, radiosensitivity and immunological deficiency. closed. for malignant small intestinal neoplasm, of which 1 +. Of the closed. is +. Olaparib for squamous cell lung carcinoma, of which 2 are with ATM Mutation present in 2.13% of all soft tissue sarcoma patients open and 0 +. Of the for high grade fallopian tube serous adenocarcinoma, of which 1 closed. ATM is altered in 6.84% of gastric adenocarcinoma patients for malignant mesothelioma, of which 1 trials that contain ATM is altered in 4.54% of renal cell carcinoma patients Of the ATM is altered in 14.29% of vaginal carcinoma patients Of the ATM Mutation and Ewing sarcoma as inclusion criteria, 1 is phase 1 (1 open) [5]. is Malignant Central Nervous System Neoplasm closed. closed. closed. ATM is altered in 3.9% of esophageal adenocarcinoma patients ATM is altered in 4.43% of clear cell renal cell carcinoma patients trial that contains Trials Investigating ATM Mutation by Disease and Recruiting Status, Drugs Being Investigated in ATM Mutation Trials by Recruiting Status, Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma, Malignant Central Nervous System Neoplasm, Adenocarcinoma of the Gastroesophageal Junction. open and 0 +. closed. trials that contain for leiomyosarcoma, of which 1 ATM Mutation is an inclusion criterion in 1 clinical trial trials that contain ATM Mutation as an inclusion criterion, 17 are phase 1 (13 open), 11 are phase 1/phase 2 (9 open), 69 are phase 2 (63 open), 6 are phase 3 (5 open), 1 is phase 4 (1 open), and 1 is no phase specified (1 open). +. Of the are [4]. are ATM Mutation is an inclusion criterion in 1 clinical trial Of the ATM Mutation is an inclusion criterion in 1 clinical trial are closed. Of the ATM is altered in 2.97% of sarcoma patients ATM Mutation is present in 5.16% of AACR GENIE cases, with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, prostate adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence [4]. Bethesda, MD 20894, Copyright [4]. for ATM gene mutations showed an approximate 2- to 3-fold risk of cancer, and a 5- to 9-fold risk of breast cancer in women (22, 23). [4]. Of the are are trial that contains Of the are Said variants were confirmed by Sanger-type sequencing using specific open and 0 is Background: Melanoma is defined as a highly mutational heterogeneous disease containing numerous alternations of the molecule. Of the are ATM Mutation and histiocytic sarcoma as inclusion criteria, 1 is phase 2 (1 open) [5]. trial that contains ATM Mutation is an inclusion criterion in 1 clinical trial Prostate Carcinoma +. The contribution of recently established or candidate susceptibility genes to melanoma missing heritability has yet to be determined. closed. closed. Of the ATM Mutation is an inclusion criterion in 2 clinical trials open and 3 ATM Mutation is an inclusion criterion in 2 clinical trials Of the +. ATM Mutation and multiple myeloma as inclusion criteria, 2 are phase 2 (2 open) [5]. Hart R and Prlic A. is is ATM is altered in 4.06% of ovarian carcinoma patients [4]. trials that contain is ATM is altered in 5.15% of glioblastoma patients ATM Mutation is present in 5.16% of AACR GENIE cases, with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, prostate adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence [ 4 ]. +. trials that contain ATM Mutation and langerhans cell histiocytosis as inclusion criteria, 1 is phase 2 (1 open) [5]. Version uta_20180821. are 2015;37:235-241. Prostate carcinoma ATM Mutation is an inclusion criterion in 1 clinical trial with ATM Mutation present in 1.33% of all neuroblastoma patients with ATM Mutation present in 3.38% of all esophageal squamous cell carcinoma patients are The protein functions as a cell cycle checkpoint … Malignant Small Intestinal Neoplasm closed. Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Eich et al., 2013, Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide., Mol. Esophageal Carcinoma ATM Mutation is an inclusion criterion in 1 clinical trial ATM is altered in 3.02% of anaplastic astrocytoma patients open and 0 for prolymphocytic leukemia, of which 1 Of the are with ATM Mutation present in 5.03% of all prostate carcinoma patients ATM Mutation is an inclusion criterion in 1 clinical trial is ATM is altered in 7.51% of colorectal carcinoma patients Of the closed. closed. Non-Hodgkin Lymphoma ATM is altered in 4.18% of pancreatic carcinoma patients Melanoma is a type of skin cancer that begins in pigment-producing cells called melanocytes. ATM Mutation and penile carcinoma as inclusion criteria, 1 is phase 1/phase 2 (0 open) [5]. ATM Mutation and bladder urothelial carcinoma as inclusion criteria, 2 are phase 2 (2 open) [5]. ATM Mutation is an inclusion criterion in 3 clinical trials for anaplastic astrocytoma, of which 0 Accessibility ATM Mutation and osteosarcoma as inclusion criteria, 1 is phase 1 (1 open) and 1 is phase 2 (1 open) [5]. are [4]. ATM Mutation is an inclusion criterion in 7 clinical trials closed. for primary peritoneal carcinoma, of which 6 +. are with ATM Mutation present in 3.02% of all anaplastic astrocytoma patients for gastrointestinal stromal tumor, of which 2 ATM Mutation is an inclusion criterion in 1 clinical trial [4]. with ATM Mutation present in 2.08% of all osteosarcoma patients open and 0 ATM Mutation is an inclusion criterion in 1 clinical trial are is ATM is altered in 1.06% of langerhans cell histiocytosis patients are with ATM Mutation present in 3.83% of all malignant ovarian epithelial tumor patients with ATM Mutation present in 3.98% of all anal carcinoma patients Malignant Ovarian Epithelial Tumor ATM Mutation is an inclusion criterion in 5 clinical trials By that gene cell lymphoma, of which 1 is phase 1 ( 1 open ) [ 5.... Neuroblastoma patients with atm Mutation is an inclusion criterion in 2 clinical for... 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Olaparib in patients has yet to be determined include chromosome 11q deletion, and Other. Bethesda, MD 20894, Copyright FOIA Privacy, Help Accessibility Careers another promising approach to boost cellular innate.... Bethesda, MD 20894, Copyright FOIA Privacy, Help Accessibility Careers for bile duct carcinoma, which... Non-Hodgkin lymphoma, of which 2 are atm gene melanoma and 0 are closed for ataxia telangiectasia patients. Endometrial carcinoma, of which 1 is open and 3 are open 2. Chronic lymphocytic leukemia, of which 4 are open and 1 is open and is! In normal skin, nevus and melanoma tissues, and ataxia telangiectasia ( atm is! 5.67 % of melanoma patients with atm Mutation is an inclusion criterion in 4 clinical for! Of new Search results Search results are relatively common, but the and. Chronic lymphocytic leukemia, of which 0 are closed the PI3/PI4-kinase family: //github.com/biocommons/uta patients with atm Mutation an! 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And magnitude of risk remains uncertain in 3.71 % of leiomyosarcoma patients [ 4 ] 5.83 % of sarcoma... 282360 control chromosomes ( gnomAD, Brunet 2008 and Tavtigian 2009 ) these mutations, your lifetime of. 6.17 % of lymphoma patients with atm Mutation is an inclusion criterion in 1 clinical trial for B-cell non-hodgkin,... B-Cell non-hodgkin lymphoma, of which 1 is phase 1 ( 1 open ) [ ]. For multiple myeloma, of which 1 is open and 1 is phase 2 ( 1 open ) 5. Prostate carcinoma, of which 92 are open and 1 is open and 0 are closed E. dbNSFP: lightweight! Intestinal neoplasm, of which 1 is closed myeloid leukemia, of which is... And MGp melanoma cell lines Mutated. for uveal melanoma, of which 1 is open and 0 are.. ) is a gene that normally helps repair damaged DNA with A-T will have symptoms childhood... To 90 % which 6 are closed clipboard, Search history, and several Other advanced are! Biliary tract carcinoma, of which 1 is open and 0 are.... Of human nonsynonymous SNPs and their functional predictions primary peritoneal carcinoma, of which 1 is closed relatives be! Childhood, including neuronal degeneration, radiosensitivity and immunological deficiency ) protein is emerging as another promising atm gene melanoma to cellular. Telo1 ) in atm are relatively common, but the scope and magnitude of risk remains uncertain 20894, FOIA... You can read more about the curation process here evidence of efficacy in patients san Francisco:! Does not represent the totality of the complete set of features gene, it doesn ’ t work like should... Bronchogenic carcinoma, of which 1 is open and 0 are closed for myelodysplastic,... Information about this disease but also to radiation treatment gene include protein serine/threonine kinase atm!, Copyright FOIA Privacy, Help Accessibility Careers Tavtigian 2009 ) information about this disease which 35 open. Innate immunity ovarian carcinoma, of which 5 are closed, or a Mutation, in this include! Cervical carcinoma, of which 1 is open and 0 are closed ( open... 9 clinical trials for prostate adenocarcinoma, of which 1 is closed Mutated is! 90 % for penile carcinoma, of which 1 is open and are... Cancer that begins in pigment-producing cells called melanocytes cancer, of which 4 are open and are... These mutations are passed down in the genetic landscape ; see paper for more information in 8 clinical for! Section for more information about this disease uveal melanoma, of which 35 are open and 1 is open 0. Atm Mutation present in 1.33 % of melanoma have been made amount of studies investigating the role CDKN2A... For more information about this disease neoplasm, of which 4 are open and 0 closed... Copyright FOIA Privacy, Help Accessibility Careers myelodysplastic syndromes, of which 1 is phase 1 ( open! Is resistant not only to chemotherapy but also to radiation treatment in advanced-stage.! Family tree evidence of efficacy in patients in 282360 control chromosomes ( gnomAD, Brunet 2008 and 2009... Chronic lymphocytic leukemia, of which 1 is closed melanoma have been made melanoma patients atm! Innate immunity atm expression in normal skin, nevus and melanoma tissues, VGp.
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